Cristiano Ronaldo scored his 23rd goal of the season as Juventus moved seven points clear at the top of Serie A with victory over 10-man Lecce.
The visitors had Fabio Lucioni sent off for a foul in the first half before Paulo Dybala struck from outside the box just after the break.
Ronaldo drove home a powerful penalty after being brought down before setting up substitute Gonzalo Higuain.
Defender Matthijs de Ligt then headed in a late third for the dominant hosts.
Ronaldo, who also scored a penalty in the 2-0 win at Bologna on Monday, has now scored 23 goals in 24 league appearances this season.
The win means Juventus extend their advantage over title rivals Lazio, who have a game in hand and could reduce the deficit back to four points if they beat Fiorentina on Saturday.